GYKI-47261 dihydrochloride

GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1[1][2].


Cat. No.: EX-A15414	Purity: >98%

	Chemical structure of GYKI-47261 dihydrochloride

For research only, Do not use for Human!

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CAS No.	1217049-32-5
Purity	>98%
Formula	C18H17Cl3N4
Mol Weight	395.713

Reference:	[1]. Abrahám G, et al. New non competitive AMPA antagonists. Bioorg Med Chem. 2000;8(8):2127-2143. [2]. Tamási V, et al. GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer. Drug Metab Dispos. 2003;31(11):1310-1314.
CoA	CoA of GYKI-47261 dihydrochloride

Smiles:	CC1=CN2C(=N1)CC3=C(C=C(C=C3)Cl)C(=N2)C4=CC=C(C=C4)N.Cl.Cl


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